Expression of EV71-VP1, PSGL-1 and SCARB2 in Tissues of Infants with Brain Stem Encephalitis
10.3969/j.issn.1004-5619.2015.02.005
- VernacularTitle:婴幼儿脑干脑炎EV71-VP1、PSGL-1和SCARB2的表达
- Author:
Ming LI
;
Xiaoping KONG
;
Hong LIU
;
Lingxi CHENG
;
Jinglu HUANG
;
Li QUAN
;
Fangyu WU
;
Bo HAO
;
Chao LIU
;
Bin LUO
- Publication Type:Journal Article
- Keywords:
forensic pathology;
encephalitis;
enterovirus;
P-selectin glycoprotein ligand-1;
scavenger re-ceptors,class B;
infants
- From:Journal of Forensic Medicine
2015;(2):97-101,104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the correlation of enterovirus 71 (EV71), P-selectin glycoprotein ligand-1 (PSG L-1), and scavenger receptor B2 (SCARB2) and to explore the possible pathway and mechanismof EV71 infection by observing the expression of EV71, PSG L-1 and SCARB2 in tissues of infants with brain stemencephalitis. Methods T he organs and tissues of infants with EV71-VP1 positivi-ty in their brain stems were chosen. Expression and distribution of EV71-VP1, PSG L-1, and SCARB2 were detected and compared by immunohistochemistry. Results Strong staining of EV71-VP1 was ob-served in the neuron, glial cells, the inflammatory cells of perivascular cuffing, parietal cells of the gas-tric fundus gland while alveolar macrophages, intestinal gland epitheliumcells, mucosa lymphoid nodule and lymphocyte of palatine tonsil showed moderate staining and weak staining were displayed in mesen-teric lymph nodes and lymphocyte of spleen. PSG L-1 expression was detected in parietal cells of the gastric fundus gland, tonsillar crypt squamous epithelium, alveolar macrophages and leukocytes in each tissue. SCARB2 expression was observed in all the above tissues except the intestines and spleen. Con-clusion T he distribution of EV71 correlates with SCARB2 expression. SCARB2 plays an important role in virus infection and replication. Stomach may be an important site for EV71 replication.
