Comparison of Lipid-Related Ratios for Prediction of Chronic Kidney Disease Stage 3 or More in Korean Adults.
10.3346/jkms.2012.27.12.1524
- Author:
Ji Young KIM
1
;
Hee Taik KANG
;
Hye Ree LEE
;
Yong Jae LEE
;
Jae Yong SHIM
Author Information
1. Department of Family Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. hope@yuhs.ac
- Publication Type:Original Article ; Comparative Study
- Keywords:
Kidney Failure, Chronic;
Dyslipidemias;
Glomerular Filtration Rate
- MeSH:
Adult;
Aged;
Asian Continental Ancestry Group;
Cholesterol/*blood;
Cholesterol, HDL/*blood;
Cholesterol, LDL/*blood;
Cross-Sectional Studies;
Female;
Glomerular Filtration Rate;
Humans;
Male;
Middle Aged;
Nutrition Surveys;
Odds Ratio;
Predictive Value of Tests;
Prevalence;
Renal Insufficiency, Chronic/epidemiology/etiology/*metabolism;
Republic of Korea;
Risk Factors;
*Severity of Illness Index;
Triglycerides/*blood
- From:Journal of Korean Medical Science
2012;27(12):1524-1529
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dyslipidemia is implicated in increased cardiovascular risk associated with chronic kidney disease (CKD) and in the progression of renal damage. This study compared 4 different lipid-related ratios (total cholesterol [TC]/high-density lipoprotein cholesterol [HDL-C], triglyceride [TG]/HDL-C, calculated low-density lipoprotein cholesterol [c-LDL-C]/HDL-C, and non-HDL-C/HDL-C ratio) for prediction of CKD stage 3 or more to investigate the association between them. This cross-sectional study included 8,650 adults who participated in the 2007-2008 Korean National Health and Nutrition Examination Survey. The overall prevalence of CKD stage 3 or more was 6.4%. For TG/HDL-C, the prevalence with CKD stage 3 or more increased with increasing quartile group in both sexes (P value for trend = 0.046 in men, 0.002 in women) while other lipid-related ratios showed increasing prevalence only in women. In comparison with the lowest quartile of the lipid-related ratios, only the fourth quartile of TG/HDL-C was associated with the prevalence of CKD stage 3 or more in both sexes after adjustment for multiple covariates (odds ratio [OR] for TG/HDL-C-Q4, 1.82; 95% CI [confidence interval], 1.09-3.03 in men, OR 2.45; 95% CI, 1.52-3.95 in women). In conclusion, TG/HDL-C is the only lipid-related ratio that is independently associated with CKD stage 3 or more in both sexes of Koreans.
