Effect observation of autogenous bone,allograft bone and BMP synthetic bone in treatment of lumbar spondylo-listhesis
10.11659/jjssx.10E015138
- VernacularTitle:自体骨、同种异体骨及 BMP 人工合成骨治疗腰椎滑脱症的效果观察
- Author:
Zhiyong LIN
;
Renqian WEI
;
Xinghai CAO
;
Jiping ZHANG
;
Tao GUO
- Publication Type:Journal Article
- Keywords:
autogenous bone;
allograft bone;
BMP synthetic bone;
lumbar spondylolisthesis;
clinical observation
- From:
Journal of Regional Anatomy and Operative Surgery
2016;25(6):420-423,424
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of autogenous bone,allograft bone and BMP synthetic bone in the treatment of lum-bar spondylolisthesis,and provide more basis to choose transplant material.Methods A total of 96 patients with lumbar spondylolisthesis were chosen as research subjects,who were cured in our hospital from January 2014 to January 2015.They were divided into group A(who were treated with autogenous bone),group B(who were treated with allograft bone)and group C(who were treated with BMP synthetic bone), according to prospective study method.The indicators of the operation,postoperative adverse reactions,change of intervertebral disc height and bone graft fusion rate of three groups were compared.Results Difference of the operation indexes of three groups had no statistical sig-nificance(P >0.05).The incidences of adverse reactions in group A and group C had no statistically significant difference(P >0.05),but both less than that in group B,with statistically significant difference(P <0.05).The intervertebral disc height after 6,9,12 and 18 months in group A and group C had no statistically significant difference(P >0.05),but both more than that in group B,with statistically significant difference(P <0.05).Bone graft fusion rate of group C was faster than that of group A and goup B,and the graft fusion rate in 18 month in group A and C had no statistically significant difference(P >0.05).And the fusion rates of group A and C in each period were significantly higher than that of group B,with statistically significant difference(P <0.05).Total effective rate of neurologic improvement in group A and group C had no statistically significant difference(P >0.05),but both better than that of group B,with statistically significant difference (P <0.05).Conclusion BMP synthetic bone used in lumbar spondylolisthesis has the same clinical effect as autologous bone.But BMP synthetic bone has faster bone graft fusion rate than autologous bone.And it is beneficial to patients’recovery.
