Retinopathy of Prematurity in Infants Born before 25 Weeks Gestation in a Korean Single Neonatal Intensive Care Unit: Incidence, Natural History and Risk Factors.
10.3346/jkms.2012.27.12.1556
- Author:
Mingui KONG
1
;
Dong Hoon SHIN
;
Sang Jin KIM
;
Don Il HAM
;
Se Woong KANG
;
Yun Sil CHANG
;
Won Soon PARK
Author Information
1. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. sangjin.kim.md@gmail.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Retinopathy of Prematurity;
Infant, Premature;
Infant, Low Birth Weight
- MeSH:
Asian Continental Ancestry Group;
Birth Weight;
Female;
Gestational Age;
Humans;
Incidence;
Infant, Extremely Premature;
Infant, Newborn;
Intensive Care Units, Neonatal;
Kaplan-Meier Estimate;
Logistic Models;
Male;
Republic of Korea/epidemiology;
Retinopathy of Prematurity/*epidemiology/mortality;
Retrospective Studies;
Risk Factors;
Severity of Illness Index
- From:Journal of Korean Medical Science
2012;27(12):1556-1562
- CountryRepublic of Korea
- Language:English
-
Abstract:
As younger preterm infants are able to survive, more extremely preterm infants are at risk of developing retinopathy of prematurity (ROP). To investigate the incidence, progression and risk factors of ROP in extremely preterm infants in Korea, the medical records of infants born before 25 weeks gestation were retrospectively reviewed. The criteria for laser treatment agreed with type 1 ROP as defined by the Early Treatment for Retinopathy of Prematurity study. Of the 121 infants included in the analysis, 119 (98.4%) infants developed any stage ROP, including 78 infants (64.5%) with type 1 ROP. The mean postmenstrual age (PMA) at the onset of any ROP and type 1 ROP were 33.5 and 36.1 weeks, respectively. All but one infant developed type 1 ROP after 31 weeks PMA. Univariate analysis showed that duration of total parenteral nutrition and onset of any ROP (PMA) were associated with the development of type 1 ROP. In conclusion, this study shows high incidence of ROP in extremely preterm infants and suggests that, although current screening protocols are feasible for most preterm infants born before 25 weeks gestation, earlier screening before 31 weeks PMA may be necessary in infants with an unstable clinical course.
