Interventional heated chemotherapy for moderate and advanced huge primary hepatocellular carcinoma
10.11659/jjssx.1672-5042.201306012
- VernacularTitle:中晚期巨块型原发性肝癌的介入热化疗栓塞治疗
- Author:
Shu LUO
;
Fei CHEN
;
Qian GUO
- Publication Type:Journal Article
- Keywords:
primary hepatocellular carcinoma;
huge;
interventional heated chemotherapy;
transcatheter arterial chemoembolization;
thera-peutic effect
- From:
Journal of Regional Anatomy and Operative Surgery
2013;(6):611-612,614
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of the therapeutic effects of interventional heated chemotherapy( IHC) for moderate and advanced huge primary hepatocellular carcinoma and compare with transcatheter arterial chemoembolization( TACE) . Methods The 68 pa-tients with moderate and advanced huge primary hepatocellular carcinoma accepted the treatment of IHC were considered as the observation group,and 32 patients managed TACE were regarded as the control group. The therapeutic effects,living quality,secondary surgery rates,The reduced level of serum AFP,survival rate,and toxic side effects of 2 groups were contrasted. Results The effective rate of observation group was obviously higher than that of control group (79. 4% vs 56. 3%,P <0. 05),and secondary surgery rates was increased(70. 6% vs 43. 8%,P<0. 01). The ratio of increased Karnofsky score was more than 20 in observation group,which was obviously higher than that of control group(35. 3% vs 12. 5%,P<0. 01). T The reduced level of serum AFP was more than 50% in observation group,which was higher than that of control group (52. 9% vs 25. 0%,P<0. 01). The survival rate of 12,18,24 months after treatment in control group was in-creased than that in control group individually (P<0. 01). Conclusion IHC is effective for huge primary hepatocellular carcinoma and in-creases the secondary surgery rates,which is one of the safe and effective methods for huge primary hepatocellular carcinoma.
