Expression of Gankyrin in gastric carcinoma and precancerious lesions and its significance
10.11659/jjssx.11E015123
- VernacularTitle:Gankyrin 在胃癌及癌前病变中的表达及意义
- Author:
Guanrong DAI
;
Junhua TANG
;
Hongliang DING
;
Weiguo ZHAO
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
precancerious lesion;
Gankyrin;
chronic atrophic gastritis;
dysplasia
- From:
Journal of Regional Anatomy and Operative Surgery
2016;25(9):651-653,654
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of Gankyrin in gastric carcinoma and preancerious lesions (including chronic atrophic gastritis and gastric epithelial dysplasia)and its clinicopathological significance.Methods Immunohistochemical assay was performed to de-tect the Gankyrin expression in 30 casess of normal gastric mucosa,60 cases of chronic atrophic gastritis,30 cases of gastric epithelial dyspla-sia,and 84 cases of gastric carcinoma.Moreover,the relationship between Gankyrin expression and clinicopathological features of gastric car-cionma was analyzed.Results Gankyrin expression was detected in normal gastric mucosa,chronic atrophic gastritis,gastric epithelial dys-plasia,and gastric carcinoma tissues in varying degrees,and the difference of Gankyrin positive rates was significant in different gastric leions mentioned above (P <0.05).The rate of Gankyrin expression in gastric carcinoma was significantly related with the clinical stage and metas-tasis.There’s no relationship between Gankyrin expression and the age,gender of patients,size,histologic grade of gastric carcinoma.Con-clusion Gankyrin participates in both the carcinogenesis and development of gastric carcinoma.Moreover,Gankyrin is a potential target for the diagnosis,prevention and treatment of gastric carcinoma.
