Therapeutic efficacy and safety of sublingual immunotherapy in treatment of adults with seasonal allergic rhini-tis:a meta-analysis
10.11659/jjssx.01E016035
- VernacularTitle:舌下免疫治疗成人季节性变应性鼻炎的疗效和安全性Meta分析
- Author:
Hui ZHAO
;
Hong JIANG
;
Yu LONG
;
Yujie LUO
- Publication Type:Journal Article
- Keywords:
sublingual immunotherapy;
seasonal allergic rhinitis;
pollinosis;
efficacy;
safety;
meta-analysis
- From:Journal of Regional Anatomy and Operative Surgery
2016;25(4):292-296,297
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically investigate the efficacy and safety of sublingual immunotherapy( SLIT) in the treatment of a-dults with seasonal allergic rhinitis( SAR) .Methods Literature was retrieved online in CNKI,CBM,VIP,Wanfang data,PubMed,EMBase, Medline,Cochrane Library,et al.After screening literature,data collection and assessment quality,randomized controlled trials relevant to our study were selected independently based on inclusion and exclusion criteria by two researchers.Statistical analyses were conducted by RevMan 5.2 software.Results A total of 13 RCTs were enrolled.The meta-analysis revealed that SLIT provided a significant improvement in aspect of reducing Symptom Scores(SS) and Medication Scores (MS)of adults with SAR,the difference had statistical significance(P<0.000 01). Compared to placebo,SLIT could increase the rate of adverse events( AEs) in the treatment of adults with SAR compared to placebo.The fre-quently reported AEs during clinical trials were oral pruritus,tongue edema,ear pruritus,throat irritation,et al.Conclusion Sublingual im-munotherapy could improve the symptoms significantly and reduce the SS and MS in the treatment of adults with SAR.And its safety could be well tolerated.
