Expression and clinical significance of URAT1 in renal tissue of patients with uric acid nephrolithiasis
10.11659/jjssx.08E014051
- VernacularTitle:URAT1基因在尿酸结石患者肾脏的表达及其临床意义
- Author:
Jiwei YAO
;
Qianwei LI
;
Weihua FU
;
Ji ZHEN
;
Junan YAN
;
Weibing LI
- Publication Type:Journal Article
- Keywords:
URAT1;
uric acid;
nephrolithiasis
- From:
Journal of Regional Anatomy and Operative Surgery
2015;(5):484-485,486
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the metabolic profile of uric acid and the significance of the altered renal expression of urate trans-porter 1(URAT1) in patients with uric acid nephrolithiasis. Methods The data of 24 patients in our hospital from January 2012 to October 2013 were analyzed retrospectively. Participants in the research were divided into three groups:patients with uric acid nephrolithiasis,other patients with nephrolithiasis and normal participants. The basic clinical data and the related data of uric acid metabolition of participants were collected,URAT1 gene expression in renal tissures of three groups was detected by Real-time PCR technique. All data were statistically ana-lyzed and compared between these groups. Results Uric acid levels in plasma,body mass index and age were significantly higher in patients with uric acid nephrolithiasis than other two groups (P<0. 05),but urine PH value was significantly reduced in patients with uric acid neph-rolithiasis. Urine and uric acid output of 24 hours urine were no significant difference among the three groups (P>0. 05). The result of Real-time PCR suggested that the URAT1 renal expression was significantly higher in patients with uric acid nephrolithiasis than other two groups (P<0. 05). Conculusion Patients with uric acid nephrolithiasis are closely related with hyperuricemia,but unrelated with renal over-ex-cretion of uric acid. The upregulated URAT1 expression in the kidney may be an important molecular mechanism of the clinical features.
