Expression of TLR4 and TLR7 protein in cervical squamous cell carcinoma
10.11659/jjssx.06E015103
- VernacularTitle:TLR4、TLR7蛋白在宫颈鳞癌中的表达及其意义
- Author:
Huaqiang LI
;
Chunfang GUO
;
Liming XIE
;
Yongxia PAN
- Publication Type:Journal Article
- Keywords:
Toll like receptor;
cervical carcinoma;
cervical intraepithelial neoplasia;
pathology
- From:
Journal of Regional Anatomy and Operative Surgery
2015;(5):502-504,505
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of Toll like receptor 4,7 (TLR4,TLR7) protein in cervical squamous cell carcinoma ( CSCC) tissues and the relationship between expression and clinical pathological characteristics of the patients. Methods A total of 67 pa-tients with CSCC carcinoma( CSCC group) ,30 patients with cervical intraepithelial neoplasia( CIN group) and 30 patients with normal cervi-cal tissues(normal group) were detected by immunohistochemical method. The expression of TLR4,TLR7 protein and its clinical pathological characteristics of patients with CSCC in the samples were analyzed. Results TLR4,TLR7 protein positive rate of CSCC group were respec-tively 80. 60% and 76. 12%,which were significantly higher than those of CIN group (46. 67%,40. 00%) and the normal group(13. 33%, 10. 00%),the difference was statistically significant (P<0. 05). TLR4,TLR7 protein positive expression rate in CIN group was significantly higher than that in the normal group (P<0. 05). The positive expression of TLR4 protein and CSCC in patients with FIGO stage,pathological grade,depth of invasion had a significant relationship(P<0. 05),pathological grade,the positive expression of TLR7 protein and CSCC in pa-tients with invasive depth had a significant relationship(P<0. 05). Conclusion There is increased expression of TLR4,TLR7 protein in cervical tissues of CSCC patients,and a certain relationship between the factors and clinical staging,pathological grading.
