Therapeutic effect of splenic autologous transplantation on rat liver cancer induced by DEN
10.11659/jjssx.09E014014
- VernacularTitle:正性脾自体移植对DEN诱发大鼠肝癌的治疗作用
- Author:
Dianbing HAN
;
Ling LIANG
;
Zhaoyang ZHANG
;
Gang ZHAO
;
Dameng FENG
- Publication Type:Journal Article
- Keywords:
spleen;
transplantion;
liver cancer;
treatment
- From:
Journal of Regional Anatomy and Operative Surgery
2015;(2):138-139,140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of autologous transplantation of spleen on rat liver cancer induced by DEN. Methods Forty rats were randomly divided into A and B group on average. Total spleens of 40 rats were resected, which preserved in liquid nitrogen. All splenectomy rats were feeded with DEN to induce hepatocellular carcinoma. After 12 weeks ,all rats which had were successfully induced liver cancer were transplanted by autologous spleen in group A. Group B were sham operation as control. Results Survival period was significantly higher in group A than that in group B. But transplanted splenic tissue had not recovered to normal morphological structure until these rats died. Conclusion Autologous transplantation of spleen has therapeutic effect for liver cancer induced by DEN.
