Application of 3D-CRT for cervical cancer stage of ⅠA-ⅡA after radical operation
10.11659/jjssx.10E015120
- VernacularTitle:三维适形放疗在ⅠA ～ⅡA 期宫颈癌患者根治术后的应用
- Author:
Qiufang WU
;
Dingfu ZHANG
;
Xi TANG
- Publication Type:Journal Article
- Keywords:
cervical cancer;
three-dimensional conformal radiation therapy;
clinical results;
security
- From:
Journal of Regional Anatomy and Operative Surgery
2016;25(7):507-509,510
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect and safety of three dimensional conformal radiotherapy (3D-CRT)for patients with cervical cancer after radical operation in stage ⅠA to ⅡA.Methods The data of 119 patients of cervical cancer in ⅠA-ⅡA with postoperative radiotherapy in our hospital were analyzed retrospectively.Of which 56 patients were treated with 3D-CRT radiotherapy (3D-CRT group),63 patients were treated with conventional radiotherapy (conventional group).The differences radiation reactions and quality of life between two groups were compared.Results The local control rate of 3D-CRT group in the first 12 and 18 months after surgery were 87.50% and 82.14%,respectively,which were significantly higher than those of conventional group(71.43%,65.08%),the difference was statistical significance(P <0.05).The survival rate of 3D-CRT group after 1 year,2 years,3 years were respectively 91.07%,83.93%, 71.43%,compared with the conventional group (84.13%,73.02%,65.08%),the difference was not statistically significant (P >0.05). Patients of 3D-CRT group were followed up for 3 years,the median survival time was 34.29 months,which was longer than the 31.08-month of conventional group,the difference was statistically significant(χ2 =4.116,P =0.042).Quality of life of 3D-CRT group (60.81 ±4.28) point was lower than that of conventional group (63.75 ±5.03)point,and the difference was statistically significant(P <0.05).The rate of early radiation reaction(rectal reaction,vaginitis)and late radiation reaction (mild or moderate radiation proctitis)in 3D-CRT group were lower than those in the conventional group,the difference was statistically significant(P <0.05 ).Conclusion The 3D-CRT has effect on the long-term prognosis of patients with cervical cancer in stage ⅠA-ⅡA,which can significantly reduce the radiation reaction and improve the quality of life of patients.
