The inhibitory Effects of Mitomycin-C on the Development of Proliferative Vitreoretinopathy.
- Author:
Kwang Soo KIM
1
;
Se Yup LEE
;
Jong Hyun KIM
Author Information
1. Department of Ophthalmology, Keimyung University School of Medicine, Korea. kimks@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Fibroblast;
Mitomycin-C;
Proliferative Vitreoretinopathy
- MeSH:
Fibroblasts;
Intravitreal Injections;
Mitomycin*;
Rabbits;
Recurrence;
Retina;
Retinal Detachment;
Retinal Pigment Epithelium;
Retinaldehyde;
Vitreoretinopathy, Proliferative*
- From:Journal of the Korean Ophthalmological Society
2002;43(1):204-212
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the inhibitory effect of MMC on experimental PVR. METHODS: The cultured rabbit fibroblasts were pretreated with 3microgram/L and 300microgram/L concentration of MMC for 30 minutes. MMC-treated and -untreated fibroblasts were injected into vitreous cavity of pigmented rabbits and the development of PVR was compared each other. The retinal toxicity of MMC was evaluated histopathologically after 30 minutes-intravitreal infusion with the same concentration of MMC. RESULTS: On the final examination 8 weeks after intravitreal injection, the rate of PVR was 90%, 67%, and 20% in control group without MMC treatment, 3.0 microgram/L MMC-treated group, and 300 microgram/L MMC-treated group, respectively. The severity of PVR was milder in treatment groups than in non-treatment group in general, and the rate of PVR between control group and 300 microgram/L MMC-treated group was statistically significant (P<0.01). At 1 and 4 weeks of histopathologic study using the light and electromicroscopy to evaluate the retinal toxicity to MMC, the retina and retinal pigment epithelium showed similar findings in MMC-treated groups compared to non-MMC-treated control group. CONCLUSIONS: These results show that pharmacologic therapy with MMC may be useful in the prevention of development and recurrence of PVR in the management of complex retinal detachment.
