THE MECHANISM OF ENDOPLASMIC RETICULUM STRESS INDUCING ALVEOLAR EPI-THELIAL CELLS APOPTOSIS UNDERLYING ASBESTOS EXPOSURE
10.3969/j.issn.1671-332X.2014.08.003
- VernacularTitle:石棉暴露下内质网应激在肺泡上皮细胞凋亡中的作用机制
- Author:
Xu ZHOU
;
Gang LIU
- Publication Type:Journal Article
- Keywords:
Asbestos;
Endoplasmic Reticulum Stress;
Apoptosis
- From:
Modern Hospital
2014;(8):9-10,13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of endoplasmic reticulum stress ( ERS) in asbestos-induced Alveolar epithelial cell apoptosis.Methods A549 cells were treated with asbestos to observe the expression of ERS proteins and apop-tosis gene by immunofluorescence staining and western blotting.Results Under asbestos exposure, the expression of Bip, GRP94, IRE-1α, BAX and BAK are up-regulated.There is a positive correlativity of the expression of proteins to the ex-posure time of asbestos.Conclusion Endoplasmic reticulum stress takes part in asbestos-induced apoptosis.
