Effect of Heroin on DLG4 Expression in Hippocampus, Amygdala and Frontal Cortex of Rats
10.3969/j.issn.1004-5619.2015.03.003
- VernacularTitle:海洛因对大鼠海马、杏仁核和额叶皮质DLG4的影响
- Author:
Liangming LUO
;
Qun GONG
;
Jianfeng LIU
;
Mingquan ZHAO
;
Dongdong CHEN
;
Yaoyao XIE
;
Hua ZHU
- Publication Type:Journal Article
- Keywords:
forensic pathology;
heroin dependence;
hippocam pus;
am ygdala;
frontal cortex;
D L G 4;
rats
- From:
Journal of Forensic Medicine
2015;(3):185-187,199
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of discs large hom olog 4 (DLG4) protein in hippocam-pus, am ygdala and frontal cortex of rats and evaluate postsynaptic density in heroin dependence. Meth-ods The rat heroin dependent m odel was established by increasing intraperitoneal injection of heroin. DLG4 proteins in hippocam pus, am ygdala and frontal cortex of heroin dependent 9, 18, 36 days rats w ere detected with im munohistochem ical staining and com pared with that in the control group. Results DLG4 proteins in hippocam pus, am ygdala and frontal cortex w ere gradually reduced with extension of heroin dependent tim e. Conclusion Heroin dependence can affect postsynaptic density of hippocam pus, am ygdala and frontal cortex. The changes becom e m ore apparent with extension of heroin dependence tim e.
