Expression of PTEN in Myocardial Tissue in Coronary Heart Disease
10.3969/j.issn.1004-5619.2016.02.004
- VernacularTitle:PTEN在冠心病心肌组织中的表达
- Author:
Xuerong LI
;
Yong HE
;
Yujia LEI
;
Xihe QIN
;
Qingtao WEI
;
Xinmin PAN
;
Lijuan LI
;
Lin ZHANG
- Publication Type:Journal Article
- Keywords:
forensic pathology;
coronary arteriosclerosis;
m yocardium;
phosphatase and tensin hom olog deleted on chrom osom e ten
- From:
Journal of Forensic Medicine
2016;32(2):94-96,104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of phosphatase and tensin hom ology deleted on chrom o-som e ten (PTEN) in m yocardial tissue in patients w ith coronary heart disease, and explore the relevance betw een the expression of PTEN and the occurrence and developm ent of coronary heart disease. Methods A total of 16 death cases w ith pathological diagnosis of coronary heart disease w ere collected as experi-m ental group, and 19 cases w ithout m yocardial lesions w ere selected as control group. The expression of PTENprotein and its m RNA w ere detected by im m unohistochem istry and real-tim e fluorescence quanti-tative PC R respectively. The correlation betw een the expression of PTEN and the pathogenesis of coronary heart disease w as analyzed. Results The expression of PTENprotein in myocardium in cases w ith coro-nary heart disease w as significantly low er com pared w ith the control group (P<0.05). There w as no sta-tistical difference of the expression of PTEN m RNA betw een experim ental and control group (P>0.05). Conclusion PTEN m ay be involved in the occurrence and developm ent of coronary heart disease.
