Angiogenesis：molecular mechanism and related diseases
10.3969/j.issn.1000-4718.2016.09.032
- VernacularTitle:血管新生的分子机制与相关疾病
- Author:
Mengze ZHANG
;
Guoshen LI
;
Xintong ZHAO
;
Lu TIE
- Publication Type:Journal Article
- Keywords:
Angiogenesis;
Vascular endothelial growth factor;
Transforming growth factor-β;
Fibroblast growth factor;
Tumor
- From:
Chinese Journal of Pathophysiology
2016;32(9):1718-1722,1728
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis is the process of capillary formation from the existing blood vessels, which is regulated by many cytokines.Balance of these cytokines plays an important role in angiogenesis.Unbalance of these cytokines, lead-ing to excessive or insufficient blood vessel, relates to a variety of diseases, such as tumor, ophthalmic diseases and wound healing.Recently, it has been observed that angiogenesis is also involved in Parkinson’s disease and Alzheimer’s disease. This review mainly discusses the molecular mechanism of angiogenesis and related diseases, and emphasizes the value of targeting angiogenesis as a strategy to develop drugs for those diseases.
