Expression and clinical significance of HMGB1 and mutant p53 in cholangiocarcinoma tissues
10.3760/cma.j.issn.1673-4203.2016.04.008
- VernacularTitle:胆管癌组织中高迁移率族蛋白B1与突变型p53的表达及临床意义
- Author:
Feng QI
;
Sheng TAI
;
Ye TIAN
- Publication Type:Journal Article
- Keywords:
Bile duct neoplasms;
Immunohistochemistry;
HMGB1 protein;
mutp53
- From:
International Journal of Surgery
2016;43(4):245-248,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions and clinical significance of HMGB1 and mutp53 in bile duct carcinoma tissue.Methods The expressions of HMGB1 and mutp53 were detected by immunohistochemistry in 47 cases cholangiocarcinoma tissue and 25 cases normal biliary duct tissue,and their correlation with clinicopathological parameters of cholangiocarcinoma was analyzed.Results The expression of HMGB1 and mutp53 was positive in 78.72％ (37/47) and 63.83％ (30/47) respectively of the cases with cholangiocarcinoma tissue,and 12.00％ (3/25) and 4.00％ (1/25)respectively of the cases in normal biliary duct tissue(all P ＜0.01).The expression of HMGB1 and mutp53 in cholangiocarcinoma tissue was relating to degree of tumor differentiation,lymph node metastasis,perineural invasion and TNM-staging(all P ＜ 0.05),and no relation to age,gender,serum bilirubin level,metastasis of tumor and site of tumor(all P ＞0.05).The expression of HMGB1 was positively correlated with that of mutp53 in bile duct carcinoma tissue(r =0.574,P ＜ 0.05).Conclusion The expressions of HMGB1 and mutp53 were increased in cholangiocarcinoma tissue,both of them play critical role for the occurrence,development,invasion and metastasis of cholangiocarcinoma.
