Role and mechanism of Kupffer cells in anti-tumor immunity of hepatocellular carcinoma
10.3760/cma.j.issn.1673-4203.2016.04.020
- VernacularTitle:Kupffer细胞在肝细胞癌肿瘤免疫中的作用及其机制
- Author:
Wuyong YU
;
Junyong ZHANG
;
Jianping GONG
- Publication Type:Journal Article
- Keywords:
Macrophages;
Carcinoma,hepatocellular;
Anti-tumor immunity;
Kupffer cells
- From:
International Journal of Surgery
2016;43(4):285-288,封4
- CountryChina
- Language:Chinese
-
Abstract:
As the biggest macrophage cells population in human body and the most important immune cells in the liver,Kupffer cells play a very important role in infection,inflammation,lipid metabolism and liver transplantation,and regulates various physiological and pathological processes.However,little is known about the role and mechanism in the tumorigenesis and tumor progression of Kupffer cells which as a kind of such important immune cells.In this paper,we summarized published researches and our experimental results about Kupffer cells,and reviewed the relationship between Kupffer cells and hepatocellular carcinoma from aspects of phagocytosis,secretary and antigen presentation.We hold that,at the early age of liver diseases,Kupffer cells inhibit tumorigenesis of hepatocellular carcinoma by its functions of phagocytosis,secretary and antigen presentation;however,when inflammation persists,Kupffer cells could induce tumorigenesis of hepatocellular carcinoma by secretary mechanism.
