Research progress on susceptible gene loci of non-syndromic cleft lip with or without deft palate
10.3760/cma.j.issn.1673-4408.2016.08.010
- VernacularTitle:非综合征型唇腭裂易感基因位点研究进展
- Author:
Chen WANG
- Publication Type:Journal Article
- Keywords:
Non-syndromic cleft lip with or without cleft palate;
Susceptible gene;
Loci;
Environmental factors
- From:
International Journal of Pediatrics
2016;43(8):631-634,637
- CountryChina
- Language:Chinese
-
Abstract:
Non-syndromic cleft lip with or without cleft palate is a common birth defect with complex causes,now widely considered as the result of interactions between genetic and environmental factors.Susceptible genes of congenital cleft lip with or without cleft palate have become a focus since the whole genome sequencing was available.Numerous candidate genes which were screened out are being constantly validated by gene polymorphism detection,case-control study and meta analysis.But the results are inconsistent.In this article,we review the research progress on susceptible genes of non-syndromic cleft lip with or without cleft palate and the relationship between environmental factors and cleft lip with or without palate in recent years.
