The current diagnosis and treatment of central nervous system leukemia
10.3760/cma.j.issn.1673-4408.2016.04.012
- VernacularTitle:儿童中枢神经系统白血病的诊治进展
- Author:
Xiru YANG
- Publication Type:Journal Article
- Keywords:
Acute lymphoblastic leukemia;
Children;
Central nervous system leukemia
- From:
International Journal of Pediatrics
2016;43(4):307-310,344
- CountryChina
- Language:Chinese
-
Abstract:
Given the existence of the blood brain barrier when combined with chemotherapy in acute leukemia treatment, leukemia cells are ultimately resulted in the occurrence of central nervous system leukemia (CNSL)by escaping the damage of chemotherapy drugs.At present,CNSL diagnostic criteria mainly relies on cerebrospinal fluid examination, clinical presentation and imaging examination.There are many means that contribute to early diagnosis of CNSL, which comprise cerebrospinal fluid cytology, CT and MRI and other imaging, monitoring minimal residual disease (MRD) in cerebrospinal fluid, monitoring hydrogen sulfide in cerebrospinal fluid, testing molecular biomarker indicators.There are several methods of achieving the goal of prevention of CNSL, including direct intrathecal administration of chemotherapy, systemic administration of chemotherapy able to penetrate the blood-brain barrier, and cranial radiation.The treatment of CNSL includes chemotherapy and radiotherapy, allogeneic hematopoietic stem cell transplantation and targeted therapy.
