Application of C-reactive protein in diagnosis of chronic obstructive pulmonary disease
10.3969/j.issn.1673-4130.2016.17.006
- VernacularTitle:CRP在慢性阻塞性肺疾病诊断中的应用
- Author:
Qiongying HU
;
Chengjin AI
;
Shuang ZHANG
;
Daqian XIONG
;
Zeyou JIANG
;
Chaoming ZHANG
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
chronic obstructive pulmonary disease;
sensitivity;
specificity
- From:
International Journal of Laboratory Medicine
2016;37(17):2374-2375,2378
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of C‐reactive protein(CRP) for diagnosing chronic obstructive pulmonary disease(COPD) to dig a new marker for COPD diagnosis .Methods A total of 199 cases of COPD ,159 cases of pulmonary malig‐nant tumor and 115 individuals undergoing the physical examination were collected .The whole blood CRP level was detected in 3 groups and the detection results were compared among 3 groups .The receiver operating characteristic(ROC) curve was drawn . Then the sensitivity ,specificity and Youden′s index(YI) were calculated to find the cut‐off value of diagnosis .Results Compared with the individuals undergoing healthy physical examination ,the CRP level in the COPD patients and the patients with pulmonary malignant tumor was significantly increased ,the difference was statistically significant(P<0 .05);the area under ROC curve(AUC) was 0 .768 ,the maximal YI was 0 .418 ,the sensitivity and specificity were 64 .7% and 77 .1% respectively ,the corresponding cut‐off value was 49 .75 mg/L .Conclusion CRP has a certain diagnostic value and can serve as a new index of COPD diagnosis .
