Value of lipoprotein associated phospholipase A2 detection in risk judgment of coronary heart disease
10.3969/j.issn.1673-4130.2016.17.002
- VernacularTitle:脂蛋白相关磷脂酶A2检测对冠心病风险判断的价值
- Author:
Liangeng LIU
;
Hailing LU
;
Xingzhong ZHENG
- Publication Type:Journal Article
- Keywords:
lipoprotein-associated phospholipase A2;
coronary heart disease;
coronary arteriography
- From:
International Journal of Laboratory Medicine
2016;37(17):2364-2365,2368
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum lipoprotein associated phospholipase A2 (Lp‐PLA2) level and severity of coronary artery stenosis in the patients with coronary heart disease(CHD) and its clinical significance .Methods A total of 243 cases of CHD and suspected CHD were divided into the high‐risk group(at least 1 coronary artery vessel stenosis >50% ,n=102) and low‐risk group(single coronary artery vessel stenosis≤50% ,n=141) according to the coronary angiography re‐sults .The clinical data were collected and Lp‐PLA2 level was detected by ELISA .Results The serum Lp‐PLA2 level in the high‐risk group was significantly higher than that in the low‐risk group ,and the difference was statistically significant(P<0 .01) ,the sensitivity of Lp‐PLA2 for judging the high‐risk patients with CHD was 86 .3% ,the specificity was 96 .6% ,and the overall diagno‐sis accuracy was 98 .0% .Conclusion Lp‐PLA2 can better assess the risk of CHD patients and the serum Lp‐PLA2 level can reflect the severity of coronary artery lesion .
