Therapeutical effect of Allicin for colitis mice induced by DSS and its possible mechanisms

VernacularTitle:Allicin对DSS诱导的小鼠结肠炎的治疗作用及可能机制
Author: Jing CHEN ; Qiaoxia LI ; Wei LI ; Hong LI ; Fei TANG ; Fukun WANG
Publication Type:Journal Article
Keywords: Allicin; Animal model; Ulcerative colitis; Apoptosis; Inflammation
From: Chinese Journal of Immunology 2016;32(7):1039-1041,1049
CountryChina
Language:Chinese
Abstract: Objective:To analyze the therapeutical effect of Allicin for colitis mice induced by DSS and its possible mechanisms. Methods:A total of 24 male mice were randomly divided into Control group,DSS group(2. 5% DSS,7 days) and Allicin group [DSS treatment and Allicin,10 mg/(kg·d),7 d]. Disease activity index,inflammatory score,TUNEL and Western bolt were performed to analyze the effect of Allicin on colitis induced by DSS. Results: With DSS group, the Allicin group had lower disease activity score and inflammatory score(P<0. 05). Allicin group had a lower number of intestinal epithelial cell apoptosis than that of DSS group,the difference was statistically significant(P<0. 05). Western bolt analysis shown that Allicin treatment significantly depressed the expression of p-JAK2 and p-STAT3 in intestinal mucosa when compared with these of DSS group ( P<0. 05 ) . Conclusion:Conclusion Allicin has significantly therapeutic effect on mice colitis induced by DSS, the possible mechanisms including anti-inflammatory effects,protected of the intestinal epithelial cells and inhibition of the JAK2/STAT3 signaling pathways.