Progress of immunologic mechanisms of IL-10 in cytomegalovirus infection
10.3760/cma.j.issn.1673-4408.2016.06.003
- VernacularTitle:IL-10在巨细胞病毒感染中的免疫机制研究进展
- Author:
Shujun HONG
- Publication Type:Journal Article
- Keywords:
Cytomegalovirus;
IL-10
- From:
International Journal of Pediatrics
2016;43(6):434-436,440
- CountryChina
- Language:Chinese
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Abstract:
Cytomegalovirus is a DNA virus that has the potential to latent-reactivation in human body with immune deficiency.CMV infection is usually asymptoatic in an immunocompetent host,but it may attack immunocompromised population.IL-10 is an important immunoregulatory cytokine,it can attenuate and terminate viral response by multiple immunosuppressive ways:affecting the expression of pro-inflammatory cytokines and chemokines,regulating antigen presenting cells,and restraining effector cell and NK cell responses.Currently,many researchers report that IL-10 has close relationtship with immunologic mechanism of cytomegalovirus in host.This paper reviews the biological effect of IL-10 and effect of IL-10 in cytomegalovirus infection.
