The application of magnetic resonance spectroscopy in different cognitive impairment

VernacularTitle:磁共振波谱在不同认知功能损害中的应用
Author: Xiaokun MI ; Qingrui LIU ; Yali WANG ; Gaofeng SHI ; Zhonghui HAN ; Liru GUO
Publication Type:Journal Article
Keywords: Alzheimer’s disease; mild cognitive impairment; hydrogenproton magnetic resonance spectroscopy
From: Journal of Practical Radiology 2016;32(8):1178-1180,1229
CountryChina
Language:Chinese
Abstract: Objective To observe the differences of metabolite ratios among mild cognitive impairment (MCI),Alzheimer’s disease (AD) and normal cognitive state (NC)patients in the hippocampus.Methods According to the clinical features,patients were divided into three groups:MCI group (n=30),AD group (n=28)and NC group (n=30).All the patients were examined by 1 H MRS and compared the ratios of NAA/Cr,Ins/Cr,NAA/Ins,Cho/Cr of both the left and right side of the hippocampus.Results The NAA/Cr in MCI group and AD group were much lower than that in NC group (P <0.05).The Ins/Cr and NAA/Ins in MCI group and AD group showed significant differences compared with NC group (P <0.05).On Ins/Cr and NAA/Ins of the left side,there were significant differences among three groups (P <0.05).Conclusion 1 H MRS as a non-invasive diagnostic technique has higher sensitivity in the early diagnosis and differential diagnosis between MCI and AD patients.