Research advances on cardiac toxicity of arsenic trioxide
10.3969/j.issn.1001-1978.2016.09.003
- VernacularTitle:三氧化二砷心脏毒性研究进展
- Author:
Jingyi ZHANG
;
Guibo SUN
;
Min WANG
;
Xiaobo SUN
- Publication Type:Journal Article
- Keywords:
arsenic trioxide;
acute promyelocyte leukemia;
car-diac toxicity;
ion channels;
oxidative stress;
apoptosis
- From:
Chinese Pharmacological Bulletin
2016;32(9):1194-1197,1198
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic trioxide has a significantly positive effect on the treatment of acute promyelocyte leukemia( APL) , and it also has been proved that arsenic trioxide can protect against some other kinds of malignant tumors in recent years. However, with the further research about arsenic trioxide, the reports about car-diac toxicity of arsenic trioxide are increasing. Currently, the possible mechanisms of As2 O3-induced cardiotoxicity are mainly considered to be associated with changes in cardiac ion chan-nels, oxidative stress injury and apoptosis. Research advances on cardiac toxicity of arsenic trioxide and some ways of preven-tion are summarized.
