Effect of isocorydine on arrhythmia in rats induced by myocardial ischemia/reperfusion injury

VernacularTitle:异可利定对大鼠心肌缺血及缺血/再灌注所致心律失常的影响
Author: Hongmei WANG ; Yunshu MA ; Qiuyan HUANG ; Shujun KONG ; Hui WANG ; Lin DENG
Publication Type:Journal Article
Keywords: isocorydine; arrhythmia; myocardial is-chemia/reperfusion injury; ischemic and infarction ar-ea; rats; anti-oxidation
From: Chinese Pharmacological Bulletin 2016;32(9):1268-1271,1272
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of isocorydine on arrhythmia in rats induced by myocardial ischemia/reperfusion injury. Methods SD rats were randomly divided into 6 groups: sham group, myocardial ische-mia/reperfusion group, verapamil group and isoc-orydine group of 2. 5 , 5 , 10 mg · kg-1 , each group having 16 rats. Left anterior descending ( LAD ) was tied up to establish the injury model of myocardial is-chemia. ECG was recorded for analysis. The ischemic and infarction area was measured and indexes of SOD, MDA, GSH-Px in the myocardial were determined. Re-sults Isocorydine could significantly reduce the inci-dence of arrhythmia induced by ischemic/reperfusion, including VT, VF;and reduce ischemic and infarction area. Further study demonstrated that isocorydine could increase myocardial SOD and GSH-Px, but de-crease myocardial MDA. Conclusion Isocorydine has a protective effect on the myocardial ischemia/reperfu-sion injury, which might be related to its anti-oxidative function.