The research progress of lncRNA as CeRNA in gastric cancer

VernacularTitle:lncRNA作为竞争性内源RNA调控胃癌进程的研究进展
Author: Xianzhe DONG ; Yuan HU ; Ping LIU ; Yupan LU
Publication Type:Journal Article
Keywords: long non-coding RNAs; competing endogenous RNAs; gastric cancer; microRNA; miRNA response elements; target genes
From: Chinese Pharmacological Bulletin 2016;32(9):1185-1188,1189
CountryChina
Language:Chinese
Abstract: Recent studies have showed that RNAs regulate each other with microRNA ( miRNA ) response elements ( MREs ) , and this mechanism is known as “competing endogenous RNA (ceRNA)” hypothesis. Long noncoding RNAs(lncRNAs) are non-protein coding transcripts longer than 200 nucleotides. Ab-errant expression of lncRNAs has been found associated with gastric cancer, one of the most malignant tumors. Compelling evidence suggests that lncRNAs can interact with miRNAs and regulate the expression of miRNAs as ceRNAs. Several lncRNAs such as GAPLINC, BC032469, H19, HOTAIR, FER1L4 and MEG3 have been found to be associated with miRNAs in gastric cancer( GC) . It is tempting to speculate that a multitude of ln-cRNAs may interrupt definitive steps in GC suppressive and on-cogenic pathways. The uncovering of the underlying mechanisms of lncRNAs may benefit our understanding of gastric cancer′s pathogenesis.