Application value of serum pregnancy-asscociated plasma protein A in primiparous women of gestational diabetes mellitus

VernacularTitle:妊娠相关血浆蛋白A在初产妇妊娠期糖尿病中的应用价值
Author: Xiwen WEI ; Kai LI ; Ruhong TAN ; Shufen CHEN ; Xiangxin LI
Publication Type:Journal Article
Keywords: pregnancy-associated plasma protein A; gestational diabetes mellitus; early pregnancy
From: International Journal of Laboratory Medicine 2016;37(15):2129-2130,2133
CountryChina
Language:Chinese
Abstract: Objective To assess the correlation between the pregnancy‐associated plasma protein A (PAPP‐A)level with gesta‐tional diabetes mellitus(GDM )in primiparous women .Methods The nonparametric test and Logistic regression analysis were used to retrospectively analyze 168 pregnant women of GDM and 273 normal pregnant women ,including age ,body weight ,PAPP‐A ,freeβ‐human chorionic gonadotropin(fβ‐hCG) .Results The age had significant difference between GDM group and control group(P<0 .01) ,the PAPP‐A concentration and corrected multiple of the median (MoM )of PAPP‐A in the GDM group were significantly lower than those in the control group(P<0 .01) .Conclusion Low level of PAPP‐A during early pregnant stage in primiparas is strongly associated with GDM and can be used as the risk factor of GDM .