The expression and clinical significance of microRNA -22 in gastric cancer

VernacularTitle:胃癌组织中微小RNA-22的表达及临床意义
Author: Lihua HU ; Peng CHEN ; Dongjie LIU ; Jiye ZHANG ; Yingjuan CHANG ; Jianying ZHANG
Publication Type:Journal Article
Keywords: Gastric neoplasms; Micro RNA -22
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(17):2561-2563,2564
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and clinical value of miRNA -22 in gastric cancer tissues.Methods Real -time PCR was used to detect the miRNA -22 expression in gastric cancer tissues and matched adjacent tissues.The correlations of miRNA -22 expression with clinic pathological features were analyzed. Results 87.5%(77 /88)of the gastric tumor tissues showed aberrant down regulation of miRNA -22 compared with adjacent non -tumor tissues (χ2 =69.32,P <0.05).Lower miRNA -22 level was strongly associated with T3 -T4 stage (χ2 =64.38,P <0.05)and lymph node metastasis(χ2 =68.56,P <0.05).The correlation statistical analysis results indicated that there were no significant differencec in sex,age and differentiation grade (all P >0.05 ). Conclusion The lower expression of miRNA -22 is associated with clinic pathological features.