Clinical effect of combination therapy of ornidazole and pefloxacin on chronic periodontitis

VernacularTitle:奥硝唑、培氟沙星联合治疗慢性牙周炎疗效观察
Author: Qifeng LUO ; Dandan WU
Publication Type:Journal Article
Keywords: Periodontitis; Ornidazole; Pefloxacin
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(17):2676-2679,2680
CountryChina
Language:Chinese
Abstract: Objective To evaluate combination therapy effects of ornidazole and pefloxacin on chronic periodontitis.Methods 200 cases of chronic periodontitis were chosen from the Stomatological Hospital of Hangzhou as study subjects.100 cases in observation group were treated with ornidazole and pefloxacin combination treatment, while another 100 cases in control group were treated with ornidazole.The treatments lasted 7 days.The effects and inflammation -related perimeters (including hs -CRP,IL -4,IL -6,IFN -γ)in patients'serum were measured. Results Probing depth,attachment loss and inflammation -related perimeters of the observation group were improved significantly,and even were much better than the control group (probing depth:t =2.113,P <0.05;attachment loss:t =1.894,P <0.05,hypersensitive C -reactive protein:t =2.001,P <0.05;IL -6:t =1.953,P <0.05;interferon -γ:t =1.976,P <0.05).And the total effective rate of the observation group was also better than that of the control group (χ2 =24.335,P <0.01).Conclusion Combination treatment of ornidazole and pefloxacin is more effective than single treatment of ornidazole,which is worthy of widely promoted in clinical.