Clinical study of irbesartan and amlodipine on the primary effect of blood pressure variability in patients with hypertension
10.3760/cma.j.issn.1008-6706.2016.16.020
- VernacularTitle:厄贝沙坦与氨氯地平对原发性高血压血压变异性的影响
- Author:
Dongmei ZHANG
;
Houmin ZHANG
- Publication Type:Journal Article
- Keywords:
Irbesartan;
Amlodipine;
Hypertension
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(16):2476-2480,2481
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of irbesartan and amlodipine on blood pressure variability (BPV) by observation of irbesartan and amlodipine in treatment of essential hypertension before and after the change of blood pressure.Methods 119 hypertensive patients were randomly divided into group A and group B according to age,sex, blood pressure,left ventricular mass index.60 patients were treated with irbesartan (group A),and another 59 patients were treated with amlodipine(group B).Liver and kidney function,blood glucose,cholesterol,low density lipoprotein,24h systolic blood pressure variation coefficient (24SCV),coefficient of variation of daytime systolic (dSCV),night systolic blood pressure variability index (nSCV),24h diastolic blood pressure coefficient of variation (24DCV),day-time diastolic blood pressure variability (dDCV),nocturnal diastolic blood pressure variation coefficient (nDCV),left ventricular mass index (LVMI),urine micro albumin,carotid intima -media thickness (IMT)level were examined at the 24th week of the therapy.Results (1 )The levels of 24h SCV,dSCV,nSCV after treatment were significantly lower than before treatment both in group A and group B (group A:24hSCV t =4.42;dSCV t =3.46;nSCV t =4.70, group B:24hSCV t =3.93;dSCV t =2.38;nSCV t =5.00,all P <0.01).Comparison of BPV between group A and group B after treatment,the 24hSCV,dSCV,nSCV of group A were lower than those of group B(24hSCV t =3.16;dSCV t =2.95,;nSCV t =2.26,all P <0.05).(2)The levels of 24hDCV,dDCV,nDCV after treatment were signifi-cantly lower than before treatment both in group A and group B(group A:24hDCV t =9.96;dDCV t =3.31;nDCV t =5.93,all P <0.01;group B:24hDCV t =5.38;dDCV t =2.19;nDCV t =5.76,all P <0.01).Comparison of BPV between group A and group B after treatment,24hDCV,dDCV,nDCV of group A were lower than those of group B (24hDCV t =2.42;dDCV t =1.44;nDCV t =2.45,all P <0.05).(3)The level of LVMI after treatment was signifi-cantly lower than before treatment both in group A and group B (group A:t =8.11,P <0.01;group B:t =7.28,all P <0.01).Comparison of LVMI between group A and group B after treatment,the LVMI of group A was lower than that of group B(t =3.75,P <0.01).(4)The level of urine micro albumin after treatment was significantly lower than before treatment both in group A and group B (group A:t =25.04;group B t =11.59,all P <0.01).Comparison of urine micro albumin between group A and group B after treatment,the level of group A was lower than that of group B (t =8.23,P <0.01).(5)The level of IMT after treatment was significantly lower than before treatment both in group A and group B (group A:t =5.58;group B t =4.10,all P <0.01).Comparison of IMT between group A and group B after treatment,the level of group A was lower than that of group B(t =1.98,P <0.05).Conclusion Irbesartan and amlodipine both can effectively reduce blood pressure and BPV.They both can protection of target organs in patients with hypertension.Irbesartan is better than amlodipine.
