The expression of CD147 and PTEN in non small cell lung cancer and their correlation with clinical pathological factors
10.3969/j.issn.1671-8348.2016.19.015
- VernacularTitle:CD147和PTEN在非小细胞肺癌中的表达及与临床病理因素的相关性分析
- Author:
Shuguang LIU
;
Zhenning ZOU
;
Hongmei MA
;
Xingen WANG
;
Jing LI
;
Shengmei XU
- Publication Type:Journal Article
- Keywords:
non small cell lung cancer;
immunohistochemistry;
extracellular matrix metalloproteinase inducer;
phosphatase and tensin homolog deleted on chromosome ten
- From:
Chongqing Medicine
2016;45(19):2638-2640,2644
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the expression of extracellular matrix metalloproteinase inducer (CD147)and phosphatase and tensin homolog deleted on chromosome ten(PTEN)in non small cell lung cancer (NSCLC) ,and to explore the correlations be‐tween expressions of CD147 and PTEN and those with clinicopathological factors .Methods The expressions of CD147 and PTEN proteins in tissues of 64 cases of patients with NSCLC and 10 cases of normal paracancerous tissues were determined by using im‐munohistochemical SP method .The correlations between expressions of CD147 and PTEN with clinicopathological factors were ana‐lysed ,as well .Results The expression of CD147 in NSCLC tissues(75 .00% )was significantly higher than that in paracancerous tissues(0 .00% ,P<0 .05) .The expression of CD147 was strongly associated with degrees of differentiation ,lymph node metastasis and TNM stage(P<0 .05) .The expression of PTEN in NSCLC tissues (32 .81% )was significantly lower than that in paracancerous tissues(80 .00% ,P<0 .05) .Expression of PTEN was strongly associated with TNM stage (P<0 .05) .Spearman correlation analy‐sis shown that CD147 expression was negatively correlated with PTEN expression (r= -0 .442 ,P<0 .05) .Conclusion The abnor‐mal expression of CD147 and PTEN might play an important role in the malignant progression of NSCLC .
