Study on correlation between patients with different glucose metabolism status and levels of serum IL-6 and IL-18
10.3969/j.issn.1673-4130.2016.14.031
- VernacularTitle:不同糖代谢状态患者与血清IL-6、IL-18水平的相关性研究
- Author:
Yanqiu LIU
;
Changyin XIE
;
Honglin LI
;
Xufei LI
- Publication Type:Journal Article
- Keywords:
pre-diabetes;
type 2 diabetes;
IL-6;
IL-18
- From:
International Journal of Laboratory Medicine
2016;37(14):1977-1978,1987
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between different glucose metabolism status and the IL‐6 and IL‐18 levels . Methods The pre‐diabetes group ,type 2 diabetes mellitus(T2DM) group and healthy control group(NC) were selected with 30 ca‐ses in each group .Fasting venous blood was collected for detecting fasting plasma glucose (FPG) ,triglyceride(TG) ,total cholester‐ol (TC) ,low‐density lipoprotein‐cholesterol (LDL‐C) and high‐density lipoprotein‐cholesterol (HDL‐C) levels .Serum IL‐6 and IL‐18 levels were measured by adopting the enzyme‐linked immunosorbent assay(ELISA) .Results The IL‐6 and IL‐18 levels in pre‐diabetes and T2DM groups were significant increased compared with those in the NC group ,the difference was statistically signifi‐cant (P<0 .01) .The IL‐6 level was positively correlated with FPG ,TG and IL‐18(P<0 .05) ,the IL‐18 level was positively correla‐ted with FPG ,TG and IL‐6(P<0 .05) .But IL‐6 and IL‐18 were negatively correlated with HDL‐C(P<0 .05) ,however ,had no cor‐relation with TC and LDL‐C (P>0 .05) .Conclusion IL‐6 and IL‐8 participated in the pathogenesis of T2DM ,their serum concen‐trations can be used as the evaluation indexes of pre‐diabetes screening and reverse intervention effect .
