Drug-induced liver injury:metabolic and genetic basis
10.3969/j.issn.1001-1978.2016.07.003
- VernacularTitle:药物性肝损伤的代谢、遗传学机制
- Author:
Shujie WANG
;
Pei WANG
;
Xiaotian LI
;
Lirong ZHANG
- Publication Type:Journal Article
- Keywords:
DILI;
hepatotoxicity;
metabolism;
genetics;
HLA;
CYP450
- From:
Chinese Pharmacological Bulletin
2016;32(7):898-901,902
- CountryChina
- Language:Chinese
-
Abstract:
Drug-induced liver injury ( DILI) is a significant rea-son of acute liver failure and is the main cause of therapeutic drugs withdrawal from the market .Multiple mechanisms can cul-minate in DILI , but metabolism and genetics play distinct roles in this process .This review will cover papers we consider have addressed these mechanisms of DILI in commonly used medica-tions for adults , and discuss the hot issues .The aim is to gener-ate discussion about the potential clinical significance among these researchs and point out the key areas for further study of DILI.
