Base Screening for Gastrodin Nasal in Situ Gel
- VernacularTitle:天麻素鼻腔原位凝胶的基质筛选
- Author:
Wen HE
;
Miao XIAO
;
Xianxi GUO
- Publication Type:Journal Article
- Keywords:
Gastrodin;
Nasal cavity;
In situ gel;
Base screening
- From:
China Pharmacist
2016;19(7):1385-1386,1404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To screen the best base for gastrodin nasal in situ gel ( ISG) to lay foundation for the development of gastrodin new preparation .Methods:Two bases were chosen , one was the combination of N-trimethyl chitosan ( TMC) , polyethylene glycol 4000 (PEG4000) and glycerophosphate (GP), and another was the combination of TMC, poloxamer 407 (P407), poloxamer 188 (P188) and carbomer.With the nasal cavity temperature of 35℃as the test temperature, the gelling time of the two bases was determined to screen the optimal ratio.Furthermore, gastrodin was added into the two bases , and the gelling time was determined to choose the suitable base for the drug.Results:The base of TMC-PEG4000-GP couldn’t gel in the nasal cavity temperature when combined with gastrodin , while the base of TMC-P407-P188-carbomer could gel quickly when combined with gastrodin .Conclusion:TMC-P407-P188-carbomer can be used as the base for gastrodin nasal in situ gel .
