Compatibility Stability of Muscular Amino Acids and Peptides and Nucleosides for Injection in Different In-fusions
- VernacularTitle:注射用肌氨肽苷与不同输液配伍的稳定性考察
- Author:
Shengchuan GAO
;
Fen ZHOU
;
Meitong LIU
- Publication Type:Journal Article
- Keywords:
Muscular amino acids and peptides and nucleosides for injection;
0.9％Sodium chloride injection;
5％Glucose in-jection;
10％Glucose injection;
Glucose and sodium chloride injection;
Compatibility stability
- From:
China Pharmacist
2016;19(7):1391-1394,1395
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the compatibility stability of muscular amino acids and peptides and nucleosides for injection in different infusions to provide basis for clinical application .Methods: The compatibility stability of muscular amino acids and pep-tides and nucleosides for injection respectively in 0.9%sodium chloride injection , 5% glucose injection , 10%glucose injection and glucose and sodium chloride injection was studied , and the indices included the appearance , pH value , number of insoluble particles and contents of hypoxanthine and polypeptides .Results:All the solutions were transparent .The pH value and the contents of hypoxan-thine and polypeptides showed no significant changes .When muscular amino acids and peptides and nucleosides for injection was mixed with 10%glucose injection , the number of insoluble particles (≥10 μm) was the smallest , which met the requirement in Chi-nese pharmacopoeia (2015 edition,volume Ⅳ).When it was mixed with 0.9% sodium chloride injection, 5% glucose injection and glucose and sodium chloride injection , the number of insoluble particles (≥10 μm) was beyond the limits .The number of insoluble particles (≥25 μm) in all the solutions met the requirement .Conclusion: The most suitable solvent for muscular amino acids and peptides and nucleosides for injection is 10%glucose injection .
