Simultaneous Determination of Vinyl Chloride and Vinylidene Chloride in Drug Packaging Materials Con-taining Polyvinyl Chloride/Polyvinylidene Chloride by HS-GC
- VernacularTitle:HS-GC法同时测定聚氯乙烯／聚偏二氯乙烯类药品包装材料中氯乙烯和偏二氯乙烯单体含量
- Author:
Yue CHEN
;
Hui YU
- Publication Type:Journal Article
- Keywords:
Drug packaging material;
Vinyl chloride;
Vinylidenechloride;
HS-GC
- From:
China Pharmacist
2016;19(7):1413-1414,1415
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To develop a method for the simultaneous determination of vinyl chloride and vinylidenechloride in drug packaging materials containing polyvinyl chloride /polyvinylidene chloride by HS-GC.Methods: A Stabilwax (30.0 m ×0.25 mm, 0.25 μm) capillary column and an FID detector were adopted .The headspace equivalent temperature was 80℃for 30 min and the col-umn temperature was 40℃.The inlet temperature was 190℃and the detector temperature was 210℃.N2 was used as the carrier gas . The flow rate was 1.0 ml · min-1 .Results: Vinyl chloride had a good linear relationship within the range of 0.5-2.5 μg ( r =0.996 7), and the average recovery was 90.4%(RSD=0.9%, n=9).Vinylidenechloride had a good linear relationship within the range of 1.0-5.0 μg (r=0.999 0), and the average recovery was 90.0%(RSD=0.6%, n=9).Conclusion: The method is fast and accurate in the simultaneous determination of vinyl chloride and vinylidenechloride in drug packaging materials containing polyvinyl chloride/polyvinylidene chloride .
