Study on Preparation Technology of Rutin Self-microemulsifying System by Pseudo-ternary Phase Diagram
- VernacularTitle:伪三元相图法研究芦丁自微乳化释药系统的制备工艺
- Author:
Huiru ZHAO
;
Peng ZHANG
;
Shaojing LIU
;
Hui JING
;
Yang YANG
;
Junchang BIAN
- Publication Type:Journal Article
- Keywords:
Rutin;
Self-microemulsifying drug delivery system;
Pseudo-ternary phase diagram
- From:
China Pharmacist
2016;19(7):1255-1258,1259
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the formula composition of rutin self-microemulsifying drug delivery system by pseudo-ternary phase diagram.Methods:The oil, surfactant and co-surfactant were chosen by the solubility test , and the formula of rutin self-microe-mulsifying drug delivery system was optimized by pseudo-ternary phase diagram .Results: The formula of rutin self-microemulsifying drug delivery system was with the mass ratio of oleic acid , Cremopher RH40 and absolute ethyl alcohol of 23∶36∶12 .The microemul-sion was clear transparent liquid .Conclusion:The prepared rutin self-microemulsifying drug delivery system using the optimized for-mula screened by pseudo-ternary phase diagram can increase the solubility of rutin significantly .
