Clinical features and antimicrobial resistance of lower respiratory tract in-fection with Streptococcus pneumoniae isolated from children
10.3969/j.issn.1671-9638.2016.08.009
- VernacularTitle:儿童下呼吸道肺炎链球菌感染临床特征及耐药性
- Author:
Liqun LI
;
Jing HU
;
Kai ZHOU
;
Guojin XIE
;
Xiaowei WANG
- Publication Type:Journal Article
- Keywords:
child;
Streptococcus pneumoniae;
lower respiratory tract infection;
drug resistance,microbial;
anti-microbial susceptibility testing;
rational drug use
- From:
Chinese Journal of Infection Control
2016;15(8):576-578,582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore clinical features and antimicrobial resistance of lower respiratory tract infection (LRTI)with Streptococcus pneumoniae (S .pneumoniae)isolated from children in Nanjing.Methods Clinical data of children with confirmed S .pneumoniae LRTI through sputum culture at a children’s hospital in Nanjing between July 2013 and June 2014 were analyzed retrospectively,S .pneumoniae strains were performed antimicrobial susceptibility testing through K-B method and minimum inhibitory concentration (MIC)testing.Results Among 197 children with S .pneumoniae infection,72.59% were <3 years old,63.96% occurred in autumn and winter, 57.87% had elevated leukocyte count,cough and fever were the most common clinical symptoms,complications of digestive and circulatory system were also common.The resistance rates of S .pneumoniae to azithromycin, penicillin,and erythromycin were 94.92%, 92.98%, and 88.83% respectively; the sensitivity rates to vancomycin,chloramphenicol,meropenem,ceftriaxone,and ofloxacin were all > 90%,vancomycin was up to 98.98%.Conclusion The percentage of S .pneumoniae LRTI is high in children < 3 years old,most occur in autumn and winter,resistance rates to azithromycin,penicillin,and erythromycin are all high,antimicrobial agents should be selected for the treatment of infection according to antimicrobial susceptibility testing.
