Frequency of HLA gene in MSM cohort and correlation with AIDS disease pro-gression
10.3969/j.issn.1000-484X.2016.08.022
- VernacularTitle:中国北京男男同性恋艾滋病感染者HLA分型及与疾病进展分析
- Author:
Jianping SUN
;
Huanqin SUN
;
Ning LIU
;
Guihai LIU
;
Jia CONG
;
Yonghong ZHANG
- Publication Type:Journal Article
- Keywords:
HIV;
HLA;
Men who have sex with men
- From:
Chinese Journal of Immunology
2016;32(8):1183-1186,1191
- CountryChina
- Language:Chinese
-
Abstract:
Objective:HIV-1 infection was associated with a variety of host genetic factors ,and HLA was one of the factors that contribute to the progression of disease .We analyze the frequency of HLA-A, HLA-B, HLA-C in MSM cohort , and the relationship between HLA gene with disease progression .Methods:PCR-sequence specific primer typing HLA typing was used to detect the allele frequency of HLA gene in 310 patients.HIV Molecular Immunology Database ( HLA Analysis Tools ) to analysis the frequency of HLA.Results:In MSM cohort,HLA-A*1101(34.52%) gene was the highest,followed by HLA-A*0201(31.94%),HLA-C*0102 (27.10%) and HLA-A*2402(26.45%).According to the CD4 cell count of HIV infected patients ,the results showed that there were low levels of HLA-B*4403(1.12%,P=0.0276),HLA-B*1511(2.25%,P=0.0282) and HLA-B*5701(0.37%,P=0.0491) in rapid progressors,while the HLA-C*0304(8.96%,P=0.0319) was higher than that of nonprogressors (4.56%).Conclusion: We obtained the distribution frequency data of HLA-A,HLA-B and HLA-C in MSM cohort.Our data presented here may offer potential cor-relation between dominant effect of HLA alleles and HIV-1 disease progression.And found that the HLA-B*4403,HLA-B*1511, HLA-B*5701 related to slow HIV disease progression and HLA-C*0304 related to accelerate HIV disease progression .
