Analysis on gene polymorphism of MTHFR C677Tin Han population of south China area
10.3969/j.issn.1673-4130.2016.13.017
- VernacularTitle:华南地区汉族人群亚甲基四氢叶酸还原酶基因多态性分析
- Author:
Ziqiang WU
;
Yunjian XU
- Publication Type:Journal Article
- Keywords:
M T HFR;
primary hypertension;
coronary heart disease;
gene polymorphism
- From:
International Journal of Laboratory Medicine
2016;37(13):1791-1792,1795
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution situation of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism among healthy Han population ,patients with primary hypertension and patients with hypertension complicating coro‐nary heart disease(CHD) in south China area .Methods MTHFR C677T gene polymorphism in 359 cases was detected by adopting the microarray method .The differences of genotypes frequencies were statistically compared between males and females .Results The wild type CC genotypes were common ,accounting for 54 .9% ,the mutation type CT accounted for 33 .1% and TT for 12 .0% . The distribution difference of wild type and mutation type had statistical difference between the male and female populations (P<0 .05);the TT frequency distribution had statistical difference among the patients with hypertension complicating CHD ,healthy population and patients with primary hypertension (P<0 .05) .Conclusion MTHFR C677T gene polymorphism distribution has difference between male and female populations ,and is related to the CHD occurrence in the patients with primary hypertension .
