Effect of Gui Zhi Fuling Jiaonang on ischemia and hypoxia endurance
10.7652/jdyxb201604025
- VernacularTitle:桂枝茯苓胶囊耐缺血缺氧能力的实验研究
- Author:
Xiaoshuai LIU
;
Guo WANG
;
Lin WANG
;
Xiaofei SHEN
;
Zhendong ZHONG
;
Junhui LI
;
Yunlu LIU
- Publication Type:Journal Article
- Keywords:
Gui Zhi Fuling Jiaonang;
myocardial anoxia;
myocardial ischemia
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(4):590-593,603
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of Gui Zhi Fuling Jiaonang on endurance to ischemia and hypoxia .Methods Mice were randomized into four groups :control group ,positive drug control group ,Gui Zhi Fuling Jiaonang high‐dose group (0 .93 g/kg) ,and Gui Zhi Fuling Jiaonang low‐dose group (0 .465 g/kg) . All mice were treated with corresponding drugs for 7 days .The hypoxia mice model was established through hypoxia in the closed jars , cerebral anoxia by decapitation , poisoning with sodium nitrite and isoprenaline . Then the hypoxia‐ischemia rat model was established by injecting isoproterenol . The anti‐hypoxic effects were observed . Results Compared with control group ,Gui Zhi Fuling Jiaonang high‐dose group (0 .93 g/kg) had a tendency to extend the survival time of mice model established through hypoxia in the closed jars ;Gui Zhi Fuling Jiaonang high‐dose (0 .93 g/kg) and low‐dose (0 .465 g/kg) groups had a tendency to extend the survival time of mice model established through cerebral anoxia by decapitation (P>0 .05) .Compared with that in control group ,the survival time of mice in Gui Zhi Fuling Jiaonang low‐dose group under poisoning with sodium nitrite and Gui Zhi Fuling Jiaonang high‐dose group under poisoning with isoprenaline were significantly prolonged .Besides ,Gui Zhi Fuling Jiaonang relieved myocardial tissue damage caused by ischemia and hypoxia ( P< 0 .05 ) .Conclusion Gui Zhi Fuling Jiaonang has an obviously protective effect on isoprenaline‐induced hypoxia and myocardial ischemia .
