Simvastatin enhances the radiosensitivity of esophageal squamous cell carcinoma
10.7652/jdyxb201604019
- VernacularTitle:辛伐他汀对食管癌细胞放疗敏感性的影响
- Author:
Yingying JIN
;
Yang WEI
;
Li WANG
;
Yun HE
;
Hui JIA
;
Hongbing MA
;
Xiaoli SUN
- Publication Type:Journal Article
- Keywords:
simvastatin;
esophageal squamous cell carcinoma;
radioresistance;
sensitization
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;37(4):565-568,581
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of simvastatin on the radiosensitivity of esophageal squamous cell carcinoma .Methods Interrupted radiation was used to induce the radioresistance EC 9706 ,named R‐resistant cell . The effect of simvastatin on the proliferation and radiosensitivity of EC 9706 and R‐resistant cells were examined by Cell Counting Kit‐8 assay and colony formation assay ,respectively .Results The radioresistance EC9706 ,named R‐resistant ,was induced successfully .The results of Counting Kit‐8 assay and colony formation assay indicated that simvastatin could sensitize EC9706 and the radioresistance of R‐resistant to irradiation .Conclusion Simvastatin can sensitize esophageal squamous cell carcinoma to irradiation .
