Levels of interleukin-1 family and interleukin-34 in serum of patients with ankylosing spondylitis
10.3760/cma.j.issn.1007-7480.2016.05.010
- VernacularTitle:强直性脊柱炎患者血清白细胞介素-1家族细胞因子和白细胞介素-34水平的检测
- Author:
Xiudi WU
;
Xiaotong SUN
;
Yawei TANG
;
Bing WANG
;
Zijian MA
;
Xia LI
- Publication Type:Journal Article
- Keywords:
Spondylitis,ankylosing;
Interleukin-l;
Interleukin-34
- From:
Chinese Journal of Rheumatology
2016;20(5):331-334,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily investigate the levels of interleukin (IL)-1 family and IL-34 in serum of patients with ankylosing spondylitis (AS) and their roles.Methods Serum IL-1 family levels were detected from 6 AS patients and 4 healthy controls by using protein-chip technique.Enzyme-linked immunosorbent assay (ELISA) method was used to detect the levels of serum IL-34 from 65 AS patients and 85 healthy controls and the relationships of serum IL-34 levels and clinical or laboratory features were analyzed.T test and Spearman correlation were used for statistical analysis.Results IL-1Ra [(3302±1352) pg/ml vs (10778±2764) pg/ml]and IL-36Ra [(1363±194) pg/ml vs (3875±996) pg/ml] levels were significantly down-regulated in AS patients compared with that of healthy controls (t=5.363 and 4.289 respectively,both P＜0.05).The levels of IL-1α,IL-18,IL-36α and IL-37 were increased more remarkable in AS patients than in healthy controls (t=-2.532,-5.400,-5.023 and-5.783 respectively,both P＜0.05).Moreover,serum IL-34 levels were elevated more significantly in AS patients than in healthy controls [(169±153) pg/ml vs (54±31) pg/ml,t=6.722,P＜0.01] and were positively correlated with the levels of CRP and ESR.Serum IL-34 levels were markedly up-regulated in human leukocyte antigen (HLA)-B27 positive patients than in HLA-B27 negative patients(P＜0.05).Conclusion Part of IL-1 family and IL-34 may be involved in inflammatory or immunological process of AS.
