Clinical study of tigecycline combined with cefoperazone/sulbactam for treatment of intracranial infection with drug-resistant Acinetobacter bau-mannii
10.3969/j.issn.1671-9638.2016.06.005
- VernacularTitle:替加环素联合头孢哌酮／舒巴坦治疗耐药鲍曼不动杆菌颅内感染临床研究
- Author:
Hongwei CHEN
;
Yuanhua LOU
;
Xiaoyong LI
;
Dongchao PAN
;
Dongcheng XIE
;
Dongsheng LIU
- Publication Type:Journal Article
- Keywords:
tigecycline;
Acinetobacter baumannii;
cefoperazone/sulbactam;
intracranial infection;
cerebrospinal fluid
- From:
Chinese Journal of Infection Control
2016;15(6):384-387,392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate clinic efficacy and safety of tigecycline combined with cefoperazone/sulbactam for treatment of intracranial infection with drug-resistant Acinetobacter baumannii (DRAB).Methods 12 patients with DRAB intracranial infection admitted in a department of neurosurgery between January 2014 and April 2015 were analyzed retrospectively,clinic efficacy and safety of tigecycline combined with cefoperazone/sulbactam for treatment of DRAB intracranial infection were evaluated.Results After patients received tigecycline combined with cefoperazone/sulbactam for 12-62 days (39.5 days on average), clinical symptoms and signs (including body temperature,signs of meningeal irritation)of most patients were significantly improved compared with before treat-ment,3 cases were cured,5 were markedly effective,4 abandoned or ineffective(death).The overall effective rate was 66.67%(8/12),mortality was 33.33% (4/12);bacterial clearance rate of cerebrospinal fluid (CSF)was 83.33%(10/12).Causes of death:2 were with failure of brain stem following craniocerebral trauma,1was extensive parenchymal infection,1was recurrence of intracranial infection and formation of brain abscess after withdrawing an-timicrobial agents.No significant adverse reaction occurred during the treatment period.Conclusion On the basis of keeping CSF drainage unobstructed,long course treatment of tigecycline combined with cefoperazone/sulbactam can effectively eliminate DRAB from CSF,and has a good safety.
