Effect of Gengnian Anshu Granule on Endocrine System of Climacteric Rats
- VernacularTitle:更年安舒颗粒对更年期大鼠内分泌系统的影响
- Author:
Chaonan WANG
;
Dongyan CHENG
;
Zhi LIU
;
Lin DI
- Publication Type:Journal Article
- Keywords:
Gennian Anshu granule;
Climacteric rats;
Endocrine system
- From:
China Pharmacist
2016;19(5):839-841,842
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the therapeutic effects of Gengnian Anshu granule on the endocrine system of menopausal rats. Methods:The rats aged 13-15 months received intragastrical treatment with Gengnian Anshu granule at the doses of 1. 9,0. 95 and 0. 48 g·kg - 1 ·d - 1 for 6 weeks. At the end of treatment,serum and hypothalamic hormone levels were detected,and the organ indices including uterus and ovaries were determined. Results:In the menopausal rats,Gengnian Anshu granule could significantly in-crease the serum estradiol(E2 )(P < 0. 05 or P < 0. 01),decrease serum follicle-stimulating hormone(FSH)and luteotrophic hor-mone(LH)(P < 0. 05 or P < 0. 01),increase norepinephrine(NE),dopamine(DA),5-hydroxytryptamine(5-HT)and β-endor-phine(β-EP)(P < 0. 05),increase the number of cells positive for estrogen receptor(ER)protein expression in hypothalamus(P <0. 05 or P < 0. 01),and decrease the number of cells positive for gonadotropin-releasing hormone(GnRH)protein expression(P <0. 01). Conclusion:With a multi-target action mechanism and an integral regulatory role,Gengnian Anshu granule can provide favor-able regulation against endocrine disorder in menopausal rats.
