Analysis of Individualized Drug Use of Clopidogrel through Drug Genetic Testing by Clinical Pharmacists
- VernacularTitle:利用药物基因检测指导氯吡格雷个体化用药案例分析
- Author:
Hongyan HUI
;
Xiang ZHOU
;
Ming CHEN
- Publication Type:Journal Article
- Keywords:
Genetic testing of drugs;
Clopidogrel;
Individualized medication;
Clinical pharmacists
- From:
China Pharmacist
2016;19(5):902-903,913
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study how to guide the individual dose of clopidogrel in line with the genetic testing results. Methods:Clinical pharmacists decided how to optimize the prescription of clopidogrel according to the genotype combined with the drug metabolism and drug interactions for three patients respectively with slow clopidogrel metabolism,intermediary metabolism and super fast metabolism. Results:The slow clopidogrel metabolism patient with subacute stent thrombosis after half a month of coronary stenting was switched to orally administrate with ticagrelor. The super fast metabolism patient suffered from repeatedly subcutaneous hemorrhage with antiplatelet therapy was suggested to lower the dose of clopidogrel,temporarily withdraw Maixuekang capsules and conventionally administrate with vitamin C tablets orally. The intermediary metabolism patient with late stent thrombosis co-treated with lansoprazole was suggested to increase the dose of clopidogrel or use ticagrelor instead,and when it was necessary,panxitorazole,ray Bella or the other ranitidine acid suppression drugs such as ranitidine could be considered. Conclusion:Through genetic testing and drug interactions,clinical pharmacists guide the clinical use of clopidogrel and the optimization of antiplatelet therapy.
