Efficacy Comparison of Highly Agglutinative Staphylococcin Injection at High Dose Combined with Oxaliplatin or Cisplatin with Intraperitoneal Perfusion in the Treatment of Malignant Peritoneal Effusion
- VernacularTitle:大剂量高聚金葡素注射液联合奥沙利铂、顺铂腹腔内灌注治疗恶性腹腔积液效果比较
- Author:
Ling ZHOU
;
Weiqiang ZHANG
- Publication Type:Journal Article
- Keywords:
Malignant peritoneal effusion;
Highly agglutinative staphylococcin;
Oxaliplatin;
Cisplatin
- From:
China Pharmacist
2016;19(5):920-921,941
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy and side effects of highly agglutinative staphylococcin injection at high dose combined with oxaliplatin or cisplatin with intraperitoneal perfusion in the treatment of malignant peritoneal effusion. Methods:Totally 60 patients with malignant peritoneal effusion were divided into two groups,32 cases in group A,and 28 cases in group B. Group A was treated with staphylococcin at high dose combined with oxaliplatin with intraperitoneal infusion after peritoneal cavity catheter drainage,and group B was treated with staphylococcin at high dose combined with cisplatin with intraperitoneal infusion after peritoneal cavity catheter drainage. All patients underwent the treatment once a week,and continuous four weeks for a courese. The clinical efficacy and adverse drug reactions were compared between the two groups. Results:The complete response rate of group A was 18. 8% ,and the total effective rate was 90. 7% ,which were both significantly higher than those of group B(P < 0. 05). The incidence of abdominal pain in group A was higher than that in group B(P < 0. 05),while there were no significant differences in the total incidence of adverse drug reactions and the other symptoms between the two groups(P > 0. 05). Conclusion:Staphylococcin at high dose combined with oxaliplatin with intraperitoneal perfusion is more effective than staphylococcin at high dose combined with cisplatin. Although abdominal pain in group A is obvious,the patients are able to tolerate with it after the symptomatic treatment,therefore,staphylococcin at high dose combined with oxaliplatin with intraperitoneal perfusion can be used as one of effective methods for the treatment of malignant peritoneal effusion.
