Correlation of liver cancer ultrasound blood flow characteristics and MVD and VEGF
10.3969/J.ISSN.1672-8270.2016.05.026
- VernacularTitle:肝癌超声血流特点与微血管密度及血管内皮细胞生长因子的相关性研究
- Author:
Xinyan LI
- Publication Type:Journal Article
- Keywords:
Primary liver cancer;
Color Doppler ultrasound;
Microvessel density;
Vascular endothelial growth factor;
Inmunohistochemistry
- From:
China Medical Equipment
2016;13(5):83-86,87
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the characteristics of color Doppler ultrasound of liver cancer blood test, and explore the microvessel density(MVD) and vascular endothelial growth factor(VEGF) relevance.Methods: 60 cases of primary liver cancer patients confirmed pathologically were selected. All the patients were underwent color Doppler ultrasound examination before the surgical resection. The signal of tumor blood flow was recorded from color Doppler flow imaging(CDFI), and the blood flow was graded. Simultaneously, vascular resistance index(RI) and relative perfusion rate were detected. The tumor tissue biopsy was taken from the postoperative patients and tumor tissue MVD and VEGF were detected by immunohistochemical techniques, in order to observe the relationship between blood flow characteristics and tumor tissue MVD and VEGF expression in liver cancer before intraoperative ultrasound.Results:With the increasing flow grade of liver cancer, the tumor tissue and positive expression rate of VEGF were significantly higher than MVD expression. The difference of VEGF expression and MVD between the different flow grade were significantly(x2=11.673,P<0.05;F=17.892,P<0.05). The positive rate of VEGF(85.0%) and MVD count(51 8±20.5.) in III stage patients were the highest. Spearman analysis showed that flow grade with tumor tissue VEGF and MVD was significantly correlated(x2=11.673,P<0.05). Relative perfusion rate and VEGF expression and MVD were significantly correlated(r=0.38, 0.42,P<0.05), RI and MVD was significantly associated(r=0.47,P<0.05), but there was nothing to do with VEGF expression(r=0.13,P>0.05).Conclusion: Color Doppler ultrasonography which is a non-invasive examination is to detect the hemodynamic characteristics of hepatocellular carcinoma, combined with VEGF and MVD. It can give effective evaluation to the state of liver cancer angiogenesis and provide evidence to the diagnosis, treatment and prognosis of liver cancer.
